One of the misconceptions around Python and other dynamically-typed languages is that they cannot be reliably used to build enterprise-grade software. However, almost all commercial and government enterprises already use Python in some capacity, either as glue code between disparate applications or to build the applications themselves.
Enterprise software is built for the requirements of an organization rather than the needs of an individual. Software written for enterprises often needs to integrate with legacy systems, such as existing databases and non-web applications. There are often requirements to integrate with authentication systems such as the Lightweight Directory Access Protocol (LDAP) and Active Directory (AD).
Organizations develop enterprise software with numerous custom requirements to fit the specific needs of their operating model. Therefore the software development process often becomes far more complicated due to disparate factions within an organization vying for the software to handle their needs at the expense of other factions.
The complexity due to the many stakeholders involved in the building of enterprise software leads to large budgets and extreme scrutiny by non-technical members of an organization. Typically those non-technical people place irrational emphasis on the choice of programming language and frameworks when otherwise they should not make technical design decisions.
Traditionally large organizations building enterprise software have used statically typed languages such as C++, .NET and Java. Throughout the 1980s and 1990s large companies such as Microsoft, Sun Microsystems and Oracle marketed these languages as "enterprise grade". The inherent snub to other languages was that they were not appropriate for CIOs' difficult technical environments. Languages other than Java, C++ and .NET were seen as risky and therefore not worthy of investment.
In addition, "scripting languages" such as Python, Perl and Ruby were not yet robust enough in the 1990s because their core standard libraries were still being developed. Frameworks such as Django, Flask and Rails (for Ruby) did not yet exist. The Web was just beginning and most enterprise applications were desktop apps built for Windows. Python simply wasn't made for such environments.
From the early 2000s through today the languages and ecosystems for many dynamically typed languages have greatly improved and often surpassed some aspects of other ecosystems. Python, Ruby and other previously derided languages now have vast, well-maintained open source ecosystems backed by both independent developers and large companies including Microsoft, IBM, Google, Facebook, Dropbox, Twilio and many, many others.
Python's open source libraries, especially for web development and data analysis, are some of the best maintained and fully featured pieces of code for any language.
Meanwhile, some of the traditional enterprise software development languages such as Java have languished due to underinvestment by their major corporate backers. When Oracle purchased Sun Microsystems in 2009 there was a long lag time before Java was enhanced with new language features in Java 7. Oracle also bundles unwanted adware with the Java installation, whereas the Python community would never put up with such a situation because the language is open source and does not have a single corporate controller.
Other ecosystems, such as the .NET platform by Microsoft have fared much better. Microsoft continued to invest in moving the .NET platform along throughout the early part of the new millennium.
However, Microsoft's enterprise products often have expensive licensing fees for their application servers and associated software. In addition, Microsoft is also a major backer of open source, especially Python, and their Python tools for Visual Studio provide a top-notch development environment.
The end result is that enterprise software development has changed dramatically over the past couple of decades. CIOs and technical executives can no longer ignore the progress of Python and the great open source community in the enterprise software development landscape if they want to continue delivering business value to their business side customers.
Python is widely used across large enterprise organizations but the code is often not put out as open source. If you come across projects that are appropriate for this list, contact me to let me know:
Collab by the U.S. government's Consumer Financial Protection Bureau (CFPB) agency is a corporate intranet and collaboration platform for large organizations. The project is currently running and in-use by thousands of CFPB employees.
Pants is a build system for software projects with many distinct parts and built with many different programming languages as is often the case in large organizations.
The following articles cover topics in enterprise development that are often not discussed when dealing with standard Python development.
Talk Python to Me's fourth episode interviewed PayPal's lead developer on Enterprise Python and Large-Scale Projects. They rebuke many of the myths around Python for large scale projects including the variable typing system and scalability.
Building and deploying an Enterprise Django Web App in 16 hours covers one developer's experience researching, building and deploying an enterprise application in Python and Django.
Mozilla's Enterprise InfoSec resources are programming language agnostic but very useful to developers trying to understand all the jargon that goes along with the enterprise security domain.
The end of enterprise IT is a fascinating essay that actually does not talk about Python in particular but shows how large enterprise IT departments such as the one at ING Bank have to evolve their structure, processes and tools to successfully ship software. Programming languages such as Python are more likely to be used in these updated polyglot and DevOps-driven environments.
There are a couple of solid demystifying articles in CIO magazine including this broad overview of Python in enterprises and this article on why dynamic languages are gaining share for enterprise development.
JavaWorld wrote an interesting article about Python's inroads into enterprise software development.
I gave a talk at DjangoCon 2014 on How to Solve the Top 5 Headaches with Django in the Enterprise which covered both Python and Django in large organizations.
This StackExchange answer contains a solid explanation what differentiates enterprise software from traditional software.
There was a Python subreddit thread about Python in the enterprise that's worth a look for broader opinions on Python compared to Java and .NET in enterprise environments.